This expository paper presents a general framework for representing levels and inter-level relations. The framework is intended to capture both epistemic and ontological notions of levels and to clarify the sense in which levels of explanation might or might not be related to a levelled ontology. The framework also allows us to study and compare different kinds of inter-level relations, especially supervenience and reduction but also grounding and mereological constitution. This, in turn, enables us to explore questions such as whether (...) supervenience implies explanatory reducibility and whether there can be irreducible higher-level explanations or even “emergent” higher-level properties. The paper finally discusses some further philosophical applications: to the free-will debate, the determinism-indeterminism distinction, indexicality and consciousness, and the relationship between positive and normative facts. (shrink)