Many existing biomedical vocabulary standards rest on incomplete, inconsistent or confused accounts of basic terms pertaining to diseases, diagnoses, and clinical phenotypes. Here we outline what we believe to be a logically and biologically coherent framework for the representation of such entities and of the relations between them. We defend a view of disease as involving in every case some physical basis within the organism that bears a disposition toward the execution of pathological processes. We present our view in the (...) form of a list of terms and definitions designed to provide a consistent starting point for the representation of both disease and diagnosis in information systems in the future. (shrink)

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

The COVID-19 pandemic prompted immense work on the investigation of the SARS-CoV-2 virus. Rapid, accurate, and consistent interpretation of generated data is thereby of fundamental concern. Ontologies––structured, controlled, vocabularies––are designed to support consistency of interpretation, and thereby to prevent the development of data silos. This paper describes how ontologies are serving this purpose in the COVID-19 research domain, by following principles of the Open Biological and Biomedical Ontology (OBO) Foundry and by reusing existing ontologies such as the Infectious Disease Ontology (...) (IDO) Core, which provides terminological content common to investigations of all infectious diseases. We report here on the development of an IDO extension, the Virus Infectious Disease Ontology (VIDO), a reference ontology covering viral infectious diseases. We motivate term and definition choices, showcase reuse of terms from existing OBO ontologies, illustrate how ontological decisions were motivated by relevant life science research, and connect VIDO to the Coronavirus Infectious Disease Ontology (CIDO). We next use terms from these ontologies to annotate selections from life science research on SARS-CoV-2, highlighting how ontologies employing a common upper-level vocabulary may be seamlessly interwoven. Finally, we outline future work, including bacteria and fungus infectious disease reference ontologies currently under development, then cite uses of VIDO and CIDO in host-pathogen data analytics, electronic health record annotation, and ontology conflict-resolution projects. (shrink)

Vaccine research, as well as the development, testing, clinical trials, and commercial uses of vaccines involve complex processes with various biological data that include gene and protein expression, analysis of molecular and cellular interactions, study of tissue and whole body responses, and extensive epidemiological modeling. Although many data resources are available to meet different aspects of vaccine needs, it remains a challenge how we are to standardize vaccine annotation, integrate data about varied vaccine types and resources, and support advanced vaccine (...) data analysis and inference. To address these problems, the community-based Vaccine Ontology (VO) has been developed through collaboration with vaccine researchers and many national and international centers and programs, including the National Center for Biomedical Ontology (NCBO), the Infectious Disease Ontology (IDO) Initiative, and the Ontology for Biomedical Investigations (OBI). VO utilizes the Basic Formal Ontology (BFO) as the top ontology and the Relation Ontology (RO) for definition of term relationships. VO is represented in the Web Ontology Language (OWL) and edited using the Protégé-OWL. Currently VO contains more than 2000 terms and relationships. VO emphasizes on classification of vaccines and vaccine components, vaccine quality and phenotypes, and host immune response to vaccines. These reflect different aspects of vaccine composition and biology and can thus be used to model individual vaccines. More than 200 licensed vaccines and many vaccine candidates in research or clinical trials have been modeled in VO. VO is being used for vaccine literature mining through collaboration with the National Center for Integrative Biomedical Informatics (NCIBI). Multiple VO applications will be presented. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. This approach limits the CL’s utility for cross-species data integration. To address this problem, we developed a method for the ontological representation of cells and applied this method to develop a (...) dendritic cell ontology (DC-CL). DC-CL subtypes are delineated on the basis of surface protein expression, systematically including both species-general and species-specific types and optimizing DC-CL for the analysis of flow cytometry data. This approach brings benefits in the form of increased accuracy, support for reasoning, and interoperability with other ontology resources. 104. Barry Smith, “Toward a Realistic Science of Environments”, Ecological Psychology, 2009, 21 (2), April-June, 121-130. Abstract: The perceptual psychologist J. J. Gibson embraces a radically externalistic view of mind and action. We have, for Gibson, not a Cartesian mind or soul, with its interior theater of contents and the consequent problem of explaining how this mind or soul and its psychological environment can succeed in grasping physical objects external to itself. Rather, we have a perceiving, acting organism, whose perceptions and actions are always already tuned to the parts and moments, the things and surfaces, of its external environment. We describe how on this basis Gibson sought to develop a realist science of environments which will be ‘consistent with physics, mechanics, optics, acoustics, and chemistry’. (shrink)

According to the PubMed resource from the U.S. National Library of Medicine, over 750,000 scientific articles have been published in the ~5000 biomedical journals worldwide in the year 2007 alone. The vast majority of these publications include results from hypothesis-driven experimentation in overlapping biomedical research domains. Unfortunately, the sheer volume of information being generated by the biomedical research enterprise has made it virtually impossible for investigators to stay aware of the latest findings in their domain of interest, let alone to (...) be able to assimilate and mine data from related investigations for purposes of meta-analysis. While computers have the potential for assisting investigators in the extraction, management and analysis of these data, information contained in the traditional journal publication is still largely unstructured, free-text descriptions of study design, experimental application and results interpretation, making it difficult for computers to gain access to the content of what is being conveyed without significant manual intervention. In order to circumvent these roadblocks and make the most of the output from the biomedical research enterprise, a variety of related standards in knowledge representation are being developed, proposed and adopted in the biomedical community. In this chapter, we will explore the current status of efforts to develop minimum information standards for the representation of a biomedical experiment, ontologies composed of shared vocabularies assembled into subsumption hierarchical structures, and extensible relational data models that link the information components together in a machine-readable and human-useable framework for data mining purposes. (shrink)

What we value, like, endorse, want, and prefer changes over the course of our lives. Richard Pettigrew presents a theory of rational decision making for agents who recognise that their values will change over time and whose decisions will affect those future times.

Conditionalization is one of the central norms of Bayesian epistemology. But there are a number of competing formulations, and a number of arguments that purport to establish it. In this paper, I explore which formulations of the norm are supported by which arguments. In their standard formulations, each of the arguments I consider here depends on the same assumption, which I call Deterministic Updating. I will investigate whether it is possible to amend these arguments so that they no longer depend (...) on it. As I show, whether this is possible depends on the formulation of the norm under consideration. (shrink)

According to certain normative theories in epistemology, rationality requires us to be logically omniscient. Yet this prescription clashes with our ordinary judgments of rationality. How should we resolve this tension? In this paper, I focus particularly on the logical omniscience requirement in Bayesian epistemology. Building on a key insight by Hacking :311–325, 1967), I develop a version of Bayesianism that permits logical ignorance. This includes: an account of the synchronic norms that govern a logically ignorant individual at any given time; (...) an account of how we reduce our logical ignorance by learning logical facts and how we should update our credences in response to such evidence; and an account of when logical ignorance is irrational and when it isn’t. At the end, I explain why the requirement of logical omniscience remains true of ideal agents with no computational, processing, or storage limitations. (shrink)

Hilbert’s program was an ambitious and wide-ranging project in the philosophy and foundations of mathematics. In order to “dispose of the foundational questions in mathematics once and for all,” Hilbert proposed a two-pronged approach in 1921: first, classical mathematics should be formalized in axiomatic systems; second, using only restricted, “finitary” means, one should give proofs of the consistency of these axiomatic systems. Although Gödel’s incompleteness theorems show that the program as originally conceived cannot be carried out, it had many partial (...) successes, and generated important advances in logical theory and metatheory, both at the time and since. The article discusses the historical background and development of Hilbert’s program, its philosophical underpinnings and consequences, and its subsequent development and influences since the 1930s. (shrink)

In this paper I defend what I call the argument from epistemic reasons against the moral error theory. I argue that the moral error theory entails that there are no epistemic reasons for belief and that this is bad news for the moral error theory since, if there are no epistemic reasons for belief, no one knows anything. If no one knows anything, then no one knows that there is thought when they are thinking, and no one knows that they (...) do not know everything. And it could not be the case that we do not know that there is thought when we believe that there is thought and that we do not know that we do not know everything. I address several objections to the claim that the moral error theory entails that there are no epistemic reasons for belief. It might seem that arguing against the error theory on the grounds that it entails that no one knows anything is just providing a Moorean argument against the moral error theory. I show that even if my argument against the error theory is indeed a Moorean one, it avoids Streumer's, McPherson's and Olson's objections to previous Moorean arguments against the error theory and is a more powerful argument against the error theory than Moore's argument against external world skepticism is against external world skepticism. (shrink)

Rescorla (Erkenntnis, 2020) has recently pointed out that the standard arguments for Bayesian Conditionalization assume that whenever I become certain of something, it is true. Most people would reject this assumption. In response, Rescorla offers an improved Dutch Book argument for Bayesian Conditionalization that does not make this assumption. My purpose in this paper is two-fold. First, I want to illuminate Rescorla’s new argument by giving a very general Dutch Book argument that applies to many cases of updating beyond those (...) covered by Conditionalization, and then showing how Rescorla’s version follows as a special case of that. Second, I want to show how to generalise R. A. Briggs and Richard Pettigrew’s Accuracy Dominance argument to avoid the assumption that Rescorla has identified (Briggs and Pettigrew in Noûs, 2018). In both cases, these arguments proceed by first establishing a very general reflection principle. (shrink)

Many philosophers nowadays believe Frege was right about belief, but wrong about language: The contents of beliefs need to be individuated more finely than in terms of Russellian propositions, but the contents of utterances do not. I argue that this 'hybrid view' cannot offer no reasonable account of how communication transfers knowledge from one speaker to another and that, to do so, we must insist that understanding depends upon more than just getting the references of terms right.

All humans have an equal basic moral status. They possess the same fundamental rights, and the comparable interests of each person should count the same in calculations that determine social policy. Neither supposed racial differences, nor skin color, sex, sexual orientation, ethnicity, intelligence, nor any other differences among humans negate their fundamental equal worth and dignity. These platitudes are virtually universally affirmed. A white supremacist racist or an admirer of Adolf Hitler who denies them is rightly regarded as beyond the (...) pale of civilized dialogue. However, a very simple line of argument developed by Peter Singer challenges our understanding of these platitudes and forces us to rethink the basis and nature of the moral equality of all humans. What I call the “Singer Problem” arises if one accepts that the morally significant cognitive capacities that are relevant to the determination of the fundamental moral status of a being vary from individual to individual by degree. The problem is to specify a moral principle determining fundamental moral status that assigns a superior status to humans compared to other animals on the basis of the superior cognitive capacities of humans but also assigns all human persons an equal fundamental moral status regardless of their differing cognitive capacities. More broadly posed, the problem is to specify moral principles that yield intuitively satisfactory implications for the treatment of human individuals and other individual animals given that cognitive capacities differ across species and individuals. A search for a resolution of the Singer problem leads to disappointing results. (shrink)

This paper is concerned with neo-Fregean accounts of reference to abstract objects. It develops an objection to the most familiar such accounts, due to Bob Hale and Crispin Wright, based upon what I call the 'proliferation problem': Hale and Wright's account makes reference to abstract objects seem too easy, as is shown by the fact that any equivalence relation seems as good as any other. The paper then develops a response to this objection, and offers an account of what it (...) is for abstracta to exist that is Fregean in spirit but more robust than familiar views. (shrink)

Logic has pride of place in mathematics and its 20th century offshoot, computer science. Modern symbolic logic was developed, in part, as a way to provide a formal framework for mathematics: Frege, Peano, Whitehead and Russell, as well as Hilbert developed systems of logic to formalize mathematics. These systems were meant to serve either as themselves foundational, or at least as formal analogs of mathematical reasoning amenable to mathematical study, e.g., in Hilbert’s consistency program. Similar efforts continue, but have been (...) expanded by the development of sophisticated methods to study the properties of such systems using proof and model theory. In parallel with this evolution of logical formalisms as tools for articulating mathematical theories (broadly speaking), much progress has been made in the quest for a mechanization of logical inference and the investigation of its theoretical limits, culminating recently in the development of new foundational frameworks for mathematics with sophisticated computer-assisted proof systems. In addition, logical formalisms developed by logicians in mathematical and philosophical contexts have proved immensely useful in describing theories and systems of interest to computer scientists, and to some degree, vice versa. Three examples of the influence of logic in computer science are automated reasoning, computer verification, and type systems for programming languages. (shrink)

An investigation of Frege’s various contributions to the study of language, focusing on three of his most famous doctrines: that concepts are unsaturated, that sentences refer to truth-values, and that sense must be distinguished from reference.

Accuracy arguments for the core tenets of Bayesian epistemology differ mainly in the conditions they place on the legitimate ways of measuring the inaccuracy of our credences. The best existing arguments rely on three conditions: Continuity, Additivity, and Strict Propriety. In this paper, I show how to strengthen the arguments based on these conditions by showing that the central mathematical theorem on which each depends goes through without assuming Additivity.

The Intergovernmental Panel on Climate Change has developed a novel framework for assessing and communicating uncertainty in the findings published in their periodic assessment reports. But how should these uncertainty assessments inform decisions? We take a formal decision-making perspective to investigate how scientific input formulated in the IPCC’s novel framework might inform decisions in a principled way through a normative decision model.

The proof theory of many-valued systems has not been investigated to an extent comparable to the work done on axiomatizatbility of many-valued logics. Proof theory requires appropriate formalisms, such as sequent calculus, natural deduction, and tableaux for classical (and intuitionistic) logic. One particular method for systematically obtaining calculi for all finite-valued logics was invented independently by several researchers, with slight variations in design and presentation. The main aim of this report is to develop the proof theory of finite-valued first order (...) logics in a general way, and to present some of the more important results in this area. In Systems covered are the resolution calculus, sequent calculus, tableaux, and natural deduction. This report is actually a template, from which all results can be specialized to particular logics. (shrink)

This paper discusses Frege's account of definition by induction in Grundgesetze and the two key theorems Frege proves using it.

Longtermism is the view that the most urgent global priorities, and those to which we should devote the largest portion of our resources, are those that focus on (i) ensuring a long future for humanity, and perhaps sentient or intelligent life more generally, and (ii) improving the quality of the lives that inhabit that long future. While it is by no means the only one, the argument most commonly given for this conclusion is that these interventions have greater expected goodness (...) per unit of resource devoted to them than each of the other available interventions, including those that focus on the health and well-being of the current population. In this paper, I argue that, even if we grant the consequentialist ethics upon which this argument depends, and even if we grant one of the axiologies that are typically paired with that ethics to give the argument, we are not morally required to choose an option that maximises expected utility; indeed, we might not even be permitted to do so. Instead, I will argue, if the argument's consequentialism is correct, we should choose using a decision theory that is sensitive to risk, and allows us to give greater weight to worse-case outcomes than expected utility theory does. And, I will show, such decision theories do not always recommend longtermist interventions. Indeed, sometimes, they recommend exactly the opposite: sometimes, they recommend hastening human extinction. Many, though not all, will take this as a reductio of the consequentialism or the axiology of the argument. I remain agnostic on the conclusion we should draw. (shrink)

The desirability of what actually occurs is often influenced by what could have been. Preferences based on such value dependencies between actual and counterfactual outcomes generate a class of problems for orthodox decision theory, the best-known perhaps being the so-called Allais Paradox. In this paper we solve these problems by extending Richard Jeffrey's decision theory to counterfactual prospects, using a multidimensional possible-world semantics for conditionals, and showing that preferences that are sensitive to counterfactual considerations can still be desirability maximising. (...) We end the paper by investigating the conditions necessary and sufficient for a desirability function to be an expected utility. It turns out that the additional conditions imply highly implausible epistemic principles. (shrink)

As is well-known, the formal system in which Frege works in his Grundgesetze der Arithmetik is formally inconsistent, Russell’s Paradox being derivable in it.This system is, except for minor differ...

We often learn the opinions of others without hearing the evidence on which they're based. The orthodox Bayesian response is to treat the reported opinion as evidence itself and update on it by conditionalizing. But sometimes this isn't feasible. In these situations, a simpler way of combining one's existing opinion with opinions reported by others would be useful, especially if it yields the same results as conditionalization. We will show that one method---upco, also known as multiplicative pooling---is specially suited to (...) this role when the opinions you wish to pool concern hypotheses about chances. The result has interesting consequences: it addresses the problem of disagreement between experts; and it sheds light on the social argument for the uniqueness thesis. (shrink)

Effective altruism sounds so innocuous—who could possibly be opposed to doing good more effectively? Yet it has inspired significant backlash in recent years. This paper addresses some common misconceptions and argues that the core “beneficentric” ideas of effective altruism are both excellent and widely neglected. Reasonable people may disagree on details of implementation, but all should share the basic goals or values underlying effective altruism.

How much does rationality constrain what we should believe on the basis of our evidence? According to this book, not very much. For most people and most bodies of evidence, there is a wide range of beliefs that rationality permits them to have in response to that evidence. The argument, which takes inspiration from William James' ideas in 'The Will to Believe', proceeds from two premises. The first is a theory about the basis of epistemic rationality. It's called epistemic utility (...) theory, and it says that what it is epistemically rational for you to believe is what it would be rational for you to choose if you were given the chance to pick your beliefs and, when picking them, you were to care only about their epistemic value. So, to say which beliefs are permitted, we must say how to measure epistemic value, and which decision rule to use when picking your beliefs. The second premise is a claim about attitudes to epistemic risk, and it says that rationality permits many different such attitudes. These attitudes can show up in epistemic utility theory in two ways: in the way you measure epistemic value; and in the decision rule you use to pick beliefs. This book explores the latter. The result is permissivism about epistemic rationality: different attitudes to epistemic risk lead to different choices of prior beliefs; given most bodies of evidence, different priors lead to different posteriors; and even once we fix your attitudes to epistemic risk, if they are at all risk-inclined, there is a range of different priors and therefore different posteriors they permit. (shrink)

A framework is developed for understanding what is “taken for granted” both in philosophy and in life generally, which may serve to orient philosophical inquiry and make it more effective. The framework takes in language and its development, as well as mathematics, logic, and the empirical sphere with particular reference to the exigencies of life. It is evaluated through consideration of seven philosophical issues concerned with such topics as solipsism, sense data as the route to knowledge, the possible reduction of (...) geometry to logic, and the existence and status of human rights. Various dichotomies and the notion of continuity are evidently highly strategic. (shrink)

Religion emerged among early humans because both purposive and non-purposive explanations were being employed but understanding was lacking of their precise scope and limits. Given also a context of very limited human power, the resultant foregrounding of agency and purposive explanation expressed itself in religion’s marked tendency towards anthropomorphism and its key role in legitimizing behaviour. The inevitability of death also structures the religious outlook; with ancestors sometimes assigned a role in relation to the living. Subjective elements such as the (...) experience of dreams and the internalization of moral precepts also play their part. Two important sources of variation among religions concern the adoption of a dualist or non-dualist perspective, and whether or not the religion’s early political experience is such as to generate a systematic doctrine subordinating politics to religion. The near ubiquity and endurance of religion are further illuminated by analysis of its functions and ideological role. Religion tends to be socially conservative but has the potential to be revolutionary. (shrink)

Our values change. What we value, want, desire, prefer, and how much; for nearly everyone, these will be different at different times in their life. These changes can be gradual or abrupt; they can be long-lasting or short-lived; and they can be induced by forces outside yourself or they can come from within or they can have no specific catalyst at all. Such preference change raises a number of questions for our theorising about rational choice, and these have been discussed (...) at length. In §2 and §3, I’ll outline two of these questions along with some of the putative solutions that have been proposed. But preference change also raises questions for our theorising about autonomy, and these have hardly been considered at all. In §4, I’ll outline three problems for personal autonomy; and in §5, I’ll outline one problem for political autonomy. In §6, I conclude. (shrink)

Drawing mainly from the Tractatus Logico-Philosophicus and his middle period writings, strategic issues and problems arising from Wittgenstein’s philosophy of mathematics are discussed. Topics have been so chosen as to assist mediation between the perspective of philosophers and that of mathematicians on their developing discipline. There is consideration of rules within arithmetic and geometry and Wittgenstein’s distinctive approach to number systems whether elementary or transfinite. Examples are presented to illuminate the relation between the meaning of an arithmetical generalisation or theorem (...) and its proof. An attempt is made to meet directly some of Wittgenstein’s critical comments on the mathematical treatment of infinity and irrational numbers. (shrink)

In this chapter we explain what experimental philosophy of science is, how it relates to the philosophy of science, and STS more broadly, and what sorts of contributions is can make to ongoing research in the philosophy of science.

This paper explores the relationship between Hume's Prinicple and Basic Law V, investigating the question whether we really do need to suppose that, already in Die Grundlagen, Frege intended that HP should be justified by its derivation from Law V.

Textbook on Gödel’s incompleteness theorems and computability theory, based on the Open Logic Project. Covers recursive function theory, arithmetization of syntax, the first and second incompleteness theorem, models of arithmetic, second-order logic, and the lambda calculus.

After a brief introduction and orientation (section I), this dialogue between Levinasian and Beckerian thought is approached along the lines of two major themes concerning consciousness which emerge in very different contexts and registers in their work (sections II and III), and one tantalizing question that is raised with great force by the dialogue (section IV). The two themes revolve around the subtle dialectical interplay that runs throughout the thought of both Levinas and Becker – the switching between internality and (...) externality, non-rational and rational; otherness and sameness; life and death – an interplay that is summed up in the dialectic between non-reflexive and reflexive consciousness. The Beckerian and Levinasian notions of the non-reflexive consciousness (section II) relate to their respective and in many ways convergent claims about a non-rational primal human state characterized by global vulnerability, awe and guilt, especially before the face of the other. Their analyses of reflexive consciousness (section III) relate to their interpretations of the problematic ideal of the free, self-constituting and self-mastering individual, and the impetus located therein towards the repression of what is Other to the self. Finally (section IV), the question is raised as to whether (and to what extent), following Levinas, sources of compelling ethical value might be legitimately understood as emerging out of Becker’s conception of primordial human vulnerability. (shrink)

When we abandon the neoliberal fiction that one is independent on the grounds that it is a-historic and antisocial, we realize that everyone is dependent and interdependent. In a media-driven society the self-identity of the individual is formed within the framework of the culture-ideology of consumerism from early childhood. As a result, both the environmental and social destruction have intensified. In the global era, or in the era of the global environmental crisis, self-identity as a precondition for environmentally sustainable care (...) of the self should be based on the culture-ideology of human rights and responsibilities, and on conscious self-limitation which realizes that one’s prosperity and security cannot come at the expense of others. Care of the self is about ensuring the habitability of the global environment as the primary interest of each individual. (shrink)

Methods available for the axiomatization of arbitrary finite-valued logics can be applied to obtain sound and complete intelim rules for all truth-functional connectives of classical logic including the Sheffer stroke and Peirce’s arrow. The restriction to a single conclusion in standard systems of natural deduction requires the introduction of additional rules to make the resulting systems complete; these rules are nevertheless still simple and correspond straightforwardly to the classical absurdity rule. Omitting these rules results in systems for intuitionistic versions of (...) the connectives in question. (shrink)

Parfit's On What Matters offers a rousing defence of non-naturalist normative realism against pressing metaphysical and epistemological objections. He addresses skeptical arguments based on (i) the causal origins of our normative beliefs, and (ii) the appearance of pervasive moral disagreement. In both cases, he concedes the first step to the skeptic, but draws a subsequent distinction with which he hopes to stem the skeptic's advance. I argue, however, that these distinctions cannot bear the weight that Parfit places on them. A (...) successful moral epistemology must take a harder line with the skeptic, insisting that moral knowledge can be had by those with the right kind of psychology -- no matter the evolutionary origin of the psychology, nor whether we can demonstrate its reliability over the alternatives. (shrink)

In this paper I examine the dispute between Hakwan Lau, Ned Block, and David Rosenthal over the extent to which empirical results can help us decide between first-order and higher-order theories of consciousness. What emerges from this is an overall argument to the best explanation against the first-order view of consciousness and the dispelling of the mythological notion of phenomenological overflow that comes with it.

(This is for the Cambridge Handbook of Analytic Philosophy, edited by Marcus Rossberg) In this handbook entry, I survey the different ways in which formal mathematical methods have been applied to philosophical questions throughout the history of analytic philosophy. I consider: formalization in symbolic logic, with examples such as Aquinas’ third way and Anselm’s ontological argument; Bayesian confirmation theory, with examples such as the fine-tuning argument for God and the paradox of the ravens; foundations of mathematics, with examples such as (...) Hilbert’s programme and Gödel’s incompleteness theorems; social choice theory, with examples such as Condorcet’s paradox and Arrow’s theorem; ‘how possibly’ results, with examples such as Condorcet’s jury theorem and recent work on intersectionality theory; and the application of advanced mathematics in philosophy, with examples such as accuracy-first epistemology. (shrink)

Are non-natural properties worth caring about? I consider two objections to metaethical non-naturalism. According to the intelligibility objection, it would be positively unintelligible to care about non-natural properties that float free from the causal fabric of the cosmos. According to the ethical idlers objection, there is no compelling motivation to posit non-natural normative properties because the natural properties suffice to provide us with reasons. In both cases, I argue, the objection stems from misunderstanding the role that non-natural properties play in (...) the non-naturalist's understanding of normativity. The role of non-natural properties is not to be responded to, but to "mark" which natural properties it is correct for us to respond to in certain ways. (shrink)

Satisficing Consequentialism is often rejected as hopeless. Perhaps its greatest problem is that it risks condoning the gratuitous prevention of goodness above the baseline of what qualifies as "good enough". I propose a radical new willpower-based version of the view that avoids this problem, and that better fits with the motivation of avoiding an excessively demanding conception of morality. I further demonstrate how, by drawing on the resources of an independent theory of blameworthiness, we may obtain a principled specification of (...) what counts as "good enough". (shrink)

In this paper I argue that a priori arguments fail to present any real problem for physicalism. They beg the question against physicalism in the sense that the argument will only seem compelling if one is already assuming that qualitative properties are nonphysical. To show this I will present the reverse-zombie and reverse-knowledge arguments. The only evidence against physicalism is a priori arguments, but there are also a priori arguments against dualism of exactly the same variety. Each of these parity (...) arguments has premises that are just as intuitively plausible, and it cannot be the case that both the traditional scenarios and the reverse-scenarios are all ideally conceivable. Given this one set must be merely prima facie conceivable and only empirical methods will tell us which is which. So, by the time a priori methodology will be of any use it will be too late. (shrink)