Mismatch is a prominent concept in evolutionary medicine and a number of philosophers have published analyses of this concept. The word ‘mismatch’ has been used in a diversity of ways across a range of sciences, leading these authors to regard it as a vague concept in need of philosophical clarification. Here, in contrast, we concentrate on the use of mismatch in modelling and experimentation in evolutionary medicine. This reveals a rigorous theory of mismatch within which the term ‘mismatch’ is indeed (...) used in several ways, not because it is ill-defined but because different forms of mismatch are.distinguished within the theory. Contemporary evolutionary medicine has unified the idea of ‘evolutionary mismatch’, derived from the older idea of ‘adaptive lag’ in evolution, with ideas about mismatch in development and physiology derived from the Developmental Origins of Health and Disease (DOHaD) paradigm. A number of publications in evolutionary medicine have tried to make this theoretical framework explicit. We build on these to present the theory in as simple and general a form as possible. We introduce terminology, largely drawn from the existing literature, to distinguish the different forms of mismatch. This integrative theory of mismatch captures how organisms track environments across space and time on multiple scales in order to maintain an adaptive match to the environment, and how failures of adaptive tracking lead to disease. Mismatch is a productive organising concept within this theory which helps researchers articulate how physiology, development and evolution interact with one another and with environmental change to explain health outcomes. (shrink)

The selected effects or ‘etiological’ theory of Proper function is a naturalistic and realist account of biological teleology. It is used to analyse normativity in philosophy of language, philosophy of mind, philosophy of medicine and elsewhere. The theory has been developed with a simple and intuitive view of natural selection. Traits are selected because of their positive effects on the fitness of the organisms that have them. These ‘selected effects’ are the Proper functions of the traits. Proponents argue that this (...) analysis of biological teleology has the unique advantage that the selected effect function of a trait is also a causal explanation of the trait: the trait exists because it performs this function. We show, however, that selected effect functions as currently defined explain the existence of traits only under highly restrictive assumptions about evolutionary dynamics. In many common scenarios in which traits evolve by natural selection, selected effect functions do not explain those traits. This is because definitions of selected effect function extract from any evolutionary scenario only the information that would be explanatorily relevant in the simple evolutionary scenario implicit in those definitions. When applied to more complex scenarios selected effect functions omit the key information that is explanatorily relevant in those scenarios. The assumptions required for selected effect functions to be explanatory are particularly unlikely to hold in the domain that its proponents care most about - the evolution of representation. A more adequate selected effects theory of Proper functions may be possible, but will require much greater attention to the structure of actual evolutionary explanations. (shrink)

The religious phenomenon is a complex one in many respects. In recent years an increasing number of theories on the origin and evolution of religion have been put forward. Each one of these theories rests on a Darwinian framework but there is a lot of disagreement about which bits of the framework account best for the evolution of religion. Is religion primarily a by-product of some adaptation? Is it itself an adaptation, and if it is, does it benefi ciate individuals (...) or groups? In this chapter, I review a number of theories that link religion to cooperation and show that these theories, contrary to what is often suggested in the literature, are not mutually exclusive. As I present each theory, I delineate an integrative framework that allows distinguishing the explanandum of each theory. Once this is done, it becomes clear that some theories provide good explanations for the origin of religion but not so good explanations for its maintenance and vice versa. Similarly some explanations are good explanations for the evolution of religious individual level traits but not so good explanations for traits hard to defi ne at the individual level. I suggest that to fully understand the religious phenomenon, integrating in a systematic way the different theories and the data is a more successful approach. (shrink)

Following from my criticisms of Calcott’s analysis on the permissive/instructive distinction, I rebut his claims that 1) he clarifies my measure one-to-one specificity; 2) for all intents and purposes of his analysis his notion of precision is different from my measure of one- to-one specificity; 3) Waddington box is a better and different model than the extension of Woodward’s radio I propose.